The EMPEROR-Reduced trial evaluated the efficacy and safety of empagliflozin in patients with heart failure and a reduced ejection fraction, with or without diabetes, who were receiving standard of care treatment. This module details the design and results of the trial.
EMPEROR-Reduced
EMPEROR-Reduced
EMPEROR-Reduced
EMPEROR-Reduced: trial design
EMPEROR-Reduced: key inclusion and exclusion criteria
EMPEROR-Reduced: hierarchical analysis plan
EMPEROR-Reduced: baseline characteristics
EMPEROR-Reduced: baseline characteristics related to heart failure and CV disease
EMPEROR-Reduced: baseline characteristics related to heart failure medications and device therapy
EMPEROR-Reduced
EMPEROR-Reduced: primary composite outcome of first adjudicated CV death or HHF
The effect of empagliflozin on the primary outcome was consistent across prespecified subgroups in EMPEROR-Reduced (1/2)
The effect of empagliflozin on the primary outcome was consistent across prespecified subgroups in EMPEROR-Reduced (2/2)
EMPEROR-Reduced
EMPEROR-Reduced: adjudicated total HHF
EMPEROR-Reduced: rate of decline in the eGFR
EMPEROR-Reduced
EMPEROR-Reduced: effect on individual components of the primary outcome
EMPEROR-Reduced: prespecified efficacy outcomes
EMPEROR-Reduced
EMPEROR-Reduced: laboratory and other measurements
EMPEROR-Reduced
EMPEROR-Reduced: serious AEs and prespecified AEs of interest
EMPEROR-Reduced
EMPEROR-Reduced: summary
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