The DAPA-HF trial assessed the efficacy and safety of dapagliflozin in patients with heart failure and a reduced ejection fraction, with or without diabetes. This module details the results.
DAPA-HF
DAPA-HF
DAPA-HF
DAPA-HF: trial design1,2
DAPA-HF: key inclusion and exclusion criteria1,2
DAPA-HF: hierarchical analysis plan1,2
DAPA-HF: hypothesis testing outcomes and subsequent analysis1,2
DAPA-HF: baseline characteristics (1/2)
DAPA-HF: baseline characteristics (2/2)
DAPA-HF: baseline medication
DAPA-HF
DAPA-HF: primary composite outcome of worsening HF* or CV death (1/2)
DAPA-HF: primary composite outcome of worsening HF* or CV death (2/2)
DAPA-HF: CV death
DAPA-HF: hospitalisation for heart failure
DAPA-HF: primary composite outcome* by prespecified subgroups (1/3)
DAPA-HF: primary composite outcome* by prespecified subgroups (2/3)
DAPA-HF: primary composite outcome* by prespecified subgroups (3/3)
DAPA-HF: primary composite outcome* in patients with or without T2D at baseline
DAPA-HF
DAPA-HF: secondary efficacy outcomes
DAPA-HF: all-cause mortality
DAPA-HF: secondary outcome of change in KCCQ total symptom score
DAPA-HF
In DAPA-HF, the effect of dapagliflozin on CV and HHF outcomes was generally consistent between patients with or without T2D at baseline
Effects of dapagliflozin in CV death and HHF were consistent regardless of background therapy and dose in DAPA-HF
DAPA-HF
DAPA-HF: metabolic parameters
DAPA-HF
DAPA-HF: safety summary
DAPA-HF
DAPA-HF: summary1,2
DAPA-HF: patient population
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